Disease Focus

The term cerebrovascular disease encompasses a diverse group of disorders that can present with a myriad of clinical signs and reported symptoms. For example, CADASIL can present as an early-onset vascular dementia and Moyamoya disease is rare young-onset cerebrovascular phenotype that has been poorly studied. To provide insight into most cerebrovascular diseases, a range of phenotypes will be included within the scope of our study.

Aneurysmal Subarachnoid Hemorrhage

aSAH is a bleeding in the subarachnoid space, the area between the brain and the membranes that cover it. It's often caused by head trauma and/or a ruptured brain aneurysm. The most common sign is a sudden, severe headache.

CADASIL

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy is a rare, inherited vascular disease that affects the small blood vessels in the brain.

Intracerebral Hemorrhage

ICH, also known as a brain bleed or cerebral hemorrhage, is a type of stroke caused by bleeding within the brain tissue, often due to ruptured blood vessels, and is a leading cause of disability and mortality. 

Moyamoya

Moyamoya is a rare condition characterized by progressive stenosis of the intracranial internal carotid arteries and their proximal branches and neo-vascularization around the circle of Willis. Cases will be patients diagnosed with Moyamoya based on findings on head CT/CTA, brain MRI/MRA, or catheter-based angiography.

Non-traumatic, Angiography-Negative Subarachnoid Hemorrhage

This occurs when bleeding into the space surrounding the brain (subarachnoid space) is not caused by a ruptured aneurysm or other identifiable vascular cause, despite extensive imaging.

Perimesencephalic Subarachnoid Hemorrhage

PMSAH type of subarachnoid hemorrhage (SAH) characterized by bleeding in the space between the brain and the skull, that is centered on the basal cisterns around the midbrain. In most cases (around 95%), PMSAH is non-aneurysmal, meaning the bleeding is not caused by a ruptured aneurysm, a common cause of SAH.